Solvent Free Asymmetric Anhydride Opening in a Ball Mill
2007 2 10 The mechanochemical technique of ball milling has been applied to the asymmetric opening of meso anhydrides mediated by the cinchona alkaloid quinidine. A simple workup procedure affords the products optically active dicarboxylic acid monoesters in high yields with up to 64 ee. With most substrates no column chromatography was needed. A range of
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